Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Redox Reactions01:27

Redox Reactions

189
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
189
Role of Reduced Coenzymes NADH and FADH₂01:29

Role of Reduced Coenzymes NADH and FADH₂

12.5K
The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
12.5K
Other Glycolytic Pathways01:24

Other Glycolytic Pathways

220
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
220
Oxidation and Reduction of Organic Molecules01:19

Oxidation and Reduction of Organic Molecules

7.6K
Energy production within a cell involves many coordinated chemical pathways. Most of these pathways are combinations of oxidation and reduction reactions, which occur at the same time. An oxidation reaction strips an electron from an atom in a compound, and the addition of this electron to another compound is a reduction reaction. Because oxidation and reduction usually occur together, these pairs of reactions are called redox reactions.
The removal of an electron from a molecule, results in a...
7.6K
Regulation of Metabolism01:19

Regulation of Metabolism

9.9K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.9K
Overview of Metabolism01:40

Overview of Metabolism

31.9K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
31.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD40LG/CD28-Mediated Rho GTPase Signaling Drives Survival and Chemoresistance in Non-ETP T-ALL.

International journal of molecular sciences·2026
Same author

Electrical regulation of multilayer graphene and graphene nanoscrolls using deionized water as a gate dielectric.

Nanoscale·2026
Same author

[Identification, expression profiling, and natural allelic variation analysis of the Sbsgr gene family in sorghum].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026
Same author

Highly synergistic degradation of fluoroquinolones driven by redox dual channel mechanism in Fe(â…¢)-mediated thermally activated persulfate system.

Journal of hazardous materials·2026
Same author

Rapid assessment of local disease control measures against the Marburg virus outbreak in Ethiopia in late 2025.

Infectious Disease Modelling·2026
Same author

Loneliness, unhealthy lifestyle, and incident cardiometabolic disease among middle-aged and older adults across 33 countries: a multicohort study.

European journal of preventive cardiology·2026
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Related Experiment Video

Updated: Sep 12, 2025

Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

14.1K

NADH reductive stress drives metabolic reprogramming.

Ronghui Yang1, Zihao Guo1, Binghui Li1

  • 1Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.

Trends in Cell Biology
|August 6, 2025
PubMed
Summary
This summary is machine-generated.

NADH reductive stress, an accumulation of NADH, actively signals metabolic reprogramming. This review explores its origins, regulation, and impact on diseases, positioning it as a key metabolic regulator.

Keywords:
NADH reductive stressNADH-reductive-stress-associated diseasesenergy stressmetabolic reprogrammingoxidative stress

More Related Videos

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

5.2K
Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

424

Related Experiment Videos

Last Updated: Sep 12, 2025

Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

14.1K
Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

5.2K
Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

424

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Metabolic Regulation

Background:

  • Cellular metabolism relies on redox signaling, with NADH/NAD+ as a key component.
  • NADH accumulation (reductive stress) is increasingly recognized as an active regulatory signal, not just a metabolic byproduct.

Purpose of the Study:

  • To synthesize current knowledge on NADH reductive stress.
  • To explore its origins, regulatory mechanisms, and therapeutic potential.
  • To establish NADH reductive stress as a master regulator of metabolic reprogramming.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Analysis of the interplay between NADH reductive stress, oxidative stress, and energy stress.
  • Examination of pathogenic roles in various diseases.

Main Results:

  • NADH reductive stress actively drives metabolic reprogramming.
  • It impacts cellular metabolism broadly and interacts with other cellular stresses.
  • Accumulated NADH is implicated in the pathogenesis of numerous diseases.

Conclusions:

  • NADH reductive stress is a critical regulator of metabolic reprogramming.
  • Further research into its mechanisms and therapeutic applications is warranted.
  • Understanding NADH reductive stress offers new avenues for disease intervention.