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Related Concept Videos

Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

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IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

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Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

46
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
46
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

319
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
319
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

23
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
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Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

73
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Updated: Sep 12, 2025

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Supersaturated Oxygen Delivery & Acute MI: Current Evidence, Practical Issues, and Future Research.

Adhvithi Pingili1, Mounika Reddy Vadiyala2, Maneeth Mylavarapu3

  • 1Department of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD 21218, USA.

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Supersaturated Oxygen (SSO2) Therapy shows promise for acute myocardial infarction, improving cardiac function and reducing damage. Further studies are needed to confirm long-term benefits and impact on mortality.

Keywords:
ST-elevated myocardial infarctionSupersaturated oxygenacute myocardial infarction with hyperoxemic therapyanimal modelsimproved echocardiographic regional wall motion score indexmyocardial infarction

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Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
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Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Acute myocardial infarction (MI) is a leading cause of mortality worldwide.
  • Early reperfusion via coronary angiography improves outcomes.
  • Supersaturated Oxygen (SSO2) Therapy emerges as a novel intervention for post-ischemic recovery.

Purpose of the Study:

  • To evaluate the efficacy of SSO2 therapy in improving post-myocardial infarction outcomes.
  • To assess the impact of SSO2 on left ventricular function, myocardial scarring, and cardiac morphology.

Main Methods:

  • Review of pre-clinical animal studies and early clinical trials on SSO2 therapy.
  • SSO2 therapy involves delivering oxygen at 10x normal levels to the infarcted artery before reperfusion.

Main Results:

  • Pre-clinical data show enhanced Left Ventricular Ejection Fraction (LVEF), reduced apoptosis, and smaller infarct sizes.
  • Clinical trials (e.g., AMIHOT I/II) indicate improved regional wall motion and prevention of cardiac remodeling.

Conclusions:

  • SSO2 therapy is a promising advancement for acute myocardial infarction treatment.
  • Early results suggest significant improvements in cardiac function and tissue preservation.
  • Long-term studies are essential to evaluate effects on mortality and healthcare utilization.