Rheological Properties of Hyaluronic Acid Fillers for Lip Volumization

Area of Science:

• Dermatology
• Cosmetic Science
• Rheology

Background:

• Hyaluronic acid (HA) fillers are extensively used for facial rejuvenation and lip augmentation.
• The rheological properties of HA fillers are critical for procedure efficacy, safety, aesthetic outcomes, and longevity.

Purpose of the Study:

• To evaluate and compare the rheological properties of three hyaluronic acid-based fillers: Belotero Intense, Kysse, and Volift.
• To assess their suitability for lip volumization procedures.

Main Methods:

• Analysis of 24 filler syringes (8 per brand) using a Kinexus PRO rheometer.
• Investigation of storage modulus (G'), loss modulus (G''), complex modulus (G*), phase angle (Tan(delta)), and cohesiveness.

Main Results:

• Significant rheological differences were observed among the three HA fillers.
• Volift exhibited higher complex modulus (G*), indicating greater resistance to deformation.
• Kysse demonstrated superior cohesiveness compared to the other fillers.

Conclusions:

• The distinct rheological profiles of Belotero Intense, Kysse, and Volift suggest varying clinical applications.
• Filler properties influence suitability for specific procedures like lip augmentation or deeper tissue filling.