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Microbiota-Host Interactions: Exploring Their Dynamics and Contributions to Human Diseases
Siau Wui Chin1, Zheng Yao Low1, Wei Qi Tan1
1School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, Malaysia.
Microbiologyopen
|August 7, 2025
Summary
Bacterial dysbiosis, an imbalance in gut, skin, and oral microbiota, contributes to various diseases. Understanding these interactions is key to developing new therapies for conditions like IBS and acne.
Area of Science:
- Microbiology
- Human Health
- Disease Pathogenesis
Background:
- Dysbiosis involves an imbalance in bacterial composition, leading to a loss of beneficial bacteria and an overgrowth of potentially pathogenic ones.
- Factors like diet, lifestyle, age, and chemical exposures significantly contribute to bacterial dysbiosis.
- Understanding bacterial dynamics is crucial for preventing and alleviating diseases linked to microbial imbalances.
Purpose of the Study:
- To elucidate the dynamic roles of bacteria in maintaining human health.
- To explore how bacteria-bacteria interactions influence the rise of antimicrobial resistance.
- To detail the relationship between bacterial dysbiosis and specific diseases in the gut, skin, and oral cavity.
Main Methods:
- This review synthesizes current knowledge on bacterial dysbiosis and its health implications.
- It examines the intricate relationships within microbial communities across different human body sites.
- The review discusses existing and emerging therapeutic strategies for restoring microbial balance.
Main Results:
- Bacterial dysbiosis is implicated in diseases such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), acne vulgaris (AV), atopic dermatitis (AD), periodontitis, and dental caries.
- Bacteria-bacteria interactions may play a role in the increasing prevalence of antimicrobial resistance.
- The review highlights the complex interplay of microbiota in maintaining host health.
Conclusions:
- Restoring microbial balance through interventions like probiotics, prebiotics, synbiotics, microbiota transplantation, and phage therapy is essential for treating dysbiosis-related diseases.
- Further research into bacterial interplays is vital for developing novel therapeutics.
- Understanding dysbiosis is fundamental for advancing human health and combating antimicrobial resistance.
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