Related Experiment Video
Updated: Sep 12, 2025
Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
Published on: December 27, 2024
Efficacy of Simple Oral Nutritional Supplements versus Usual Care in Postoperative Patients with Gastric Cancer: A
Kohei Ueno1, Tatsuto Nishigori1, Yukinari Tokoro1
1Department of Surgery, Kyoto University Hospital, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Objective:
To evaluate the efficacy of a simple oral nutritional supplement (ONS) without excess nutrients on body weight loss (BWL) after gastrectomy in patients with gastric cancer.
Summary Background Data:
BWL is commonly observed in the early few months after gastrectomy for gastric cancer. It is uncertain if a simple ONS with usual diet improve postoperative BWL.
Methods:
A multicenter randomized controlled trial was conducted across 19 institutions. Patients undergoing curative gastrectomy for gastric cancer were randomized into the ONS or control group. The ONS group received 400 mL (kcal)/day of ONS mainly containing carbohydrates and proteins for 8 weeks postoperatively. The primary endpoint was the percentage of BWL from baseline to postoperative 8 weeks. Secondary endpoints included handgrip strength, hematological parameters, health-related quality of life, dietary intake, and ONS adherence.
Results:
The 124 patients were randomized to the ONS group (n=62) or control group (n=62), with 2 in the ONS group lost to follow-up. The ONS group experienced significantly less weight loss at postoperative 8 weeks (-4.8% vs. -6.4%, P=0.039). No significant differences were observed in handgrip strength or hematological parameters. The incidences of adverse events were comparable between the groups (7% vs. 11%, P=0.373), but the ONS group had higher symptom scores for insomnia, appetite loss, and diarrhea during intervention. The mean ONS intake was >75% (308.7 mL±97.0 mL/d).
Conclusions:
The simple ONS for 8 weeks after gastrectomy reduced postoperative BWL in patients with gastric cancer.
Related Concept Videos
01:26Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
01:15Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease
01:24Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
01:26Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...