Applications of prussian blue analogues nanomaterials in electrochemiluminescence based biosensing: A review

Electrochemiluminescence (ECL) biosensing has emerged as a transformative technology in analytical science, driven by synergistic advancements in molecular engineering and nanomaterial design. While conventional ECL systems have achieved notable progress, persistent challenges in signal amplification stability and biorecognition efficiency necessitate innovative nanoarchitectures. Prussian blue analogues (PBAs), a class of cyanide-bridged coordination polymers, have recently garnered significant research interest due to their unique multifunctionality. Characterized by tunable redox activity, enzyme-mimetic properties, and a porous framework with abundant metal coordination sites, PBAs demonstrate exceptional potential for overcoming current limitations in ECL biosensor development. This comprehensive review systematically examines the recent analytical application and research progress of PBAs-based ECL sensors in biomedicine, discusses the advantages and potential limitations of PBAs-based ECL sensors, and looks forward to the future development directions and trends of PBAs-based ECL sensors in this field.