Silk fibroin coating on biometals: processing, anti-corrosion and biofunctionality

As a natural protein, silk fibroin (SF) has been widely used in the biomedical field due to its excellent biocompatibility. Recent research has explored its potential as a multifunctional coating for biometals. This paper comprehensively reviews the processing approaches, anti-corrosion capability, and biofunctionalization of SF coatings. The corrosion resistance and self-healing properties of SF coating in body-fluid environments have been confirmed. The biofunctional design of SF coatings, such as promoting osteogenesis, endothelialization, and antibacterial activity, has achieved significant effects. Future researches are recommended including long-term in vivo efficacy, externally regulated degradation, and application for implantable electronic devices.