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Updated: Sep 12, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
The intersection of viral mimicry and nuclear entry
Claire F Dickson1, Prabhjeet Phalora1, David A Jacques1
1Department of Molecular Medicine, School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia; EMBL Australia Node in Single Molecule Science, School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Abstract:
The nuclear pore complex (NPC) facilitates macromolecular exchange between the cytoplasm and nucleus; the selective nature of which is vital to proper cell functioning. Many DNA and some RNA viruses must also access the host nucleus for successful replication and have evolved numerous strategies for this purpose, the most common of which is mimicry of cellular cargoes. Recent biochemical studies have also identified an alternative strategy, mimicry of nuclear transport receptors (NTRs). In this Review, we summarize the multiple ways in which viral protein complexes and capsids access the nucleus and discuss how studying these interactions has reshaped our understanding of the NPC and the nature of nuclear cytoplasmic transport.
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