Related Experiment Video

Updated: Sep 12, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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[Retracted] MicroRNA‑181a regulates epithelial‑mesenchymal transition by targeting PTEN in drug‑resistant lung

Haihui Li1, Pei Zhang2, Xiaojin Sun2

  • 1Shandong University, Jinan, Shandong, P.R. China.

International Journal of Oncology
|August 8, 2025
PubMed

Insights

This study on cell migration and invasion assays was retracted due to significant data duplication concerns. The International Journal of Oncology lost confidence in the presented findings.

Area of Science:

  • Oncology
  • Cell Biology
  • Scientific Publishing Ethics

Background:

  • A study published in the International Journal of Oncology presented findings from scratch wound, cell migration, and invasion assays.
  • Concerns were raised by a reader regarding potential data manipulation in the published figures.

Purpose of the Study:

  • To address concerns of data duplication and overlapping panels in figures.
  • To evaluate the integrity of the presented experimental data.

Main Methods:

  • Review of figures (2A, 2B, 5A-C, 6A, 7B, 8B) for evidence of overlapping and duplicated data panels.
  • Microscopic image analysis to identify data duplication.

Main Results:

  • Significant evidence of overlapping data was found within and between figure panels.
  • Duplication of cell microscopic images was identified across multiple figures.
  • A large number of data duplication events were confirmed.

Conclusions:

  • The identified data duplication events led to a retraction of the paper.
  • The International Journal of Oncology lost confidence in the presented data.
  • Authors did not provide a response to the editorial office regarding the concerns.
Keywords:
PTENchemoresistanceepithelial-mesenchymal transitionlung adenocarcinomamicroRNA-181a

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