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The Correlation Between Sleep and Coronary Heart Disease: A Review

Qingbo Shi1, Yang Gao1,2, Zhuocheng Shi1

  • 1Department of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital, 450000 Zhengzhou, Henan, China.

Reviews in Cardiovascular Medicine
|August 8, 2025
PubMed

Insights

Poor sleep quality and duration are increasingly linked to coronary heart disease (CHD). This review explores the connection between sleep issues and CHD, offering insights into mechanisms and clinical guidance for prevention.

Area of Science:

  • Cardiovascular Medicine
  • Sleep Science
  • Public Health

Background:

  • Coronary heart disease (CHD) is a leading cause of global mortality, rising due to aging and lifestyle factors.
  • Established risk factors like hypertension and diabetes do not fully explain CHD's complex origins.
  • Modern life contributes to widespread sleep deprivation and poor sleep quality, prompting research into sleep's role in health.

Purpose of the Study:

  • To review the relationship between sleep duration, sleep quality, and sleep disorders with CHD.
  • To explore potential underlying biological mechanisms connecting sleep disturbances and CHD.
  • To discuss clinical implications and provide guidance for CHD prevention and treatment strategies.

Main Methods:

  • Literature review synthesizing current research on sleep and CHD.
  • Analysis of epidemiological data and mechanistic studies.
  • Examination of clinical evidence and treatment guidelines.

Main Results:

  • Growing evidence links insufficient sleep duration and poor sleep quality to increased CHD risk.
  • Specific sleep disorders are associated with heightened cardiovascular events.
  • Several potential mechanisms, including inflammation and metabolic dysregulation, are implicated.

Conclusions:

  • Sleep is a critical, yet often overlooked, factor in cardiovascular health.
  • Addressing sleep problems may offer a novel approach to CHD prevention and management.
  • Further research is needed to fully elucidate causal pathways and optimize interventions.

Keywords:
coronary heart diseasesleep disorderssleep durationsleep quality

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