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The bidirectional regulatory network between ATF4 and lncRNAs in systemic diseases
Dongdong Wu1, Mei Huang1,2, Changning Ma1
1College of Physical Education, Yanshan University, Qinhuangdao, China.
Frontiers in Oncology
|August 8, 2025
Summary
Long non-coding RNAs (lncRNAs) interact with Activating Transcription Factor 4 (ATF4) to regulate gene expression during stress. Targeting these interactions offers therapeutic potential for various diseases.
Area of Science:
- Molecular Biology
- Genetics
- Cellular Biology
Background:
- Long non-coding RNAs (lncRNAs) regulate gene expression in stress responses.
- Activating Transcription Factor 4 (ATF4) is central to the integrated stress response (ISR).
- lncRNA-ATF4 interactions are increasingly recognized in systemic diseases.
Purpose of the Study:
- To review the regulatory roles of ATF4-lncRNA interactions.
- To explore these interactions in digestive, respiratory, immune, and skeletal systems.
- To highlight therapeutic strategies targeting the ATF4-lncRNA axis.
Main Methods:
- Literature review of studies on lncRNAs and ATF4.
- Analysis of ATF4-lncRNA crosstalk in disease contexts.
- Synthesis of findings across physiological systems.
Main Results:
- lncRNAs act as both downstream targets and upstream modulators of ATF4.
- These interactions influence tumor progression, metabolism, immunity, and skeletal homeostasis.
- Specific lncRNAs play critical roles in various organ systems.
Conclusions:
- ATF4-lncRNA crosstalk is a key regulatory mechanism in stress adaptation and disease.
- Targeting lncRNAs offers a promising avenue for precision medicine.
- Further research is needed to translate these findings into therapies.
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