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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jun 26, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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Aortitis after granulocyte-colony stimulating factor administration: A case report.

Shuichi Fujiwara1, Hitomi Hara1, Naomasa Fukase1,2

  • 1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.

Biomedical Reports
|August 8, 2025
PubMed
Summary

Granulocyte-colony stimulating factor (G-CSF) can cause acute aortitis. This case study details a patient who developed aortitis after receiving pegfilgrastim, a G-CSF, following chemotherapy.

Area of Science:

  • Oncology
  • Hematology
  • Immunology

Background:

  • Granulocyte-colony stimulating factor (G-CSF) stimulates white blood cell production.
Keywords:
G-CSFadverse eventaortitischemotherapychordoma

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  • G-CSF is frequently used to mitigate neutropenia after chemotherapy.
  • Neutropenia increases infection risk and can lead to febrile neutropenia.