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Updated: Aug 17, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Engineering Bonding Types and Macromeric Cross-Linkers in the Network To Modulate the Structures and Properties of
Pei-Han Lin1, Tzu-Ying Wang1, Yi-Cheun Yeh1
1Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
Abstract:
Hybrid hydrogels are versatile biomaterials, and cross-linkers are the key for tailoring their characteristics. However, the bonding types in the network and the hydrophobic chain lengths of cross-linkers remain underexplored. This study introduces formylbenzoic acid-modified PEG (PEG-FA), which further reacts with adipic acid (AA), sebacic acid (SA), and tetradecanedioic acid (TDA) to create cross-linkers with varying hydrophobic segments. PEG-FA and its derivatives are used as aldehyde-functionalized macromeric cross-linkers to react with polydextran hydrazide (PDH) and quaternized chitosan (QCS) to form PDH/QCS hybrid hydrogels through dynamic interactions. The results indicate that increasing the hydrazone/imine ratio improves the strength and stability of the network. Notably, TDA-PEG-FA cross-linkers grant hydrogels with smaller pores and better mechanical strength. Overall, the structures and properties of PDH/QCS hydrogels can be tailored by selecting bonding types and designing macromeric cross-linkers in the network, enabling the customization of hydrogel performance for advanced applications.
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