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Diphanes: cage-like compounds featuring two cavities.

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Diphanes are dual-cavity molecular cages with potential in molecular recognition and separation. This review highlights covalent and coordination-driven synthetic strategies for designing these versatile cage compounds.

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Area of Science:

  • Supramolecular Chemistry
  • Organic Synthesis

Background:

  • Diphanes are cage-like molecules with two distinct cavities.
  • Their dual-cavity structure enables selective encapsulation and discrimination of guest molecules.
  • Potential applications include molecular recognition, separation, catalysis, and adsorption.

Purpose of the Study:

  • To provide a comprehensive overview of synthetic strategies for diphanes.
  • To highlight recent advancements in the rational design and functional applications of diphanes.
  • To inspire further research into double- and multiple-chambered molecular cages.

Main Methods:

  • Focus on two primary synthetic approaches: covalent strategies (reversible and irreversible) and coordination-driven (metal-organic) strategies.
  • Review of recent literature on diphane synthesis and applications.

Main Results:

  • Detailed discussion of covalent and coordination-driven synthetic routes for diphanes.
  • Examples of diphanes with diverse shapes and functions are presented.
  • Emphasis on the structure-property relationships in diphane design.

Conclusions:

  • Diphanes offer significant potential due to their unique dual-cavity architecture.
  • Advancements in synthetic strategies are crucial for expanding structural diversity and functions.
  • Further exploration is encouraged to unlock the full application potential of these molecular cages.