Related Experiment Video
Updated: Sep 12, 2025

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
Strategies for Restoration of Compromised First Permanent Molars in Children: Challenges and Optimal Timing
Purpose:
To evaluate restorative strategies for compromised first permanent molars in pediatric patients, with emphasis on determining the optimal timing for intervention.
Materials And Methods:
A comprehensive literature search was conducted across four electronic databases: PubMed, ScienceDirect, Scopus, and Web of Science. Among the 127 retrieved articles, 42 studies that met the predefined inclusion criteria were incorporated into the analysis.
Results:
Restoration of compromised first permanent molars can be accomplished through both direct and indirect techniques. Standardized protocols for the management of severely compromised first permanent molars are still lacking.
Conclusions:
The principal determinants guiding treatment encompass patient cooperation, defect severity, dental developmental stage, pulp status and passive eruption.
Clinical Relevance:
High-quality research is required to establish evidence-based guidelines for the restoration of compromised molars in the pediatric population.
Related Concept Videos
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...

