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Inference of Genetic Ancestry from Cancer-Derived Molecular Data with RAIDS

Pascal Belleau1,2, Astrid Deschênes2, David A Tuveson2

  • 1Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring, NY, USA.

Methods in Molecular Biology (Clifton, N.J.)
|August 8, 2025
PubMed
Summary

Researchers developed RAIDS (Robust Ancestry Inference using Data Synthesis), a new tool to determine genetic ancestry from cancer molecular data. This computational method aids in understanding ancestral influences on cancer, even without patient-matched normal DNA.

Keywords:
Continental populationsGenetic ancestryGenotypingPrincipal-component analysisSynthetic data

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