Diastereoselective construction of structurally diverse polycyclic spiroindolenines via Yb(OTf)3-catalyzed cascade
Song Hu1, Dan Hu1, Jianming Xu1
1Laboratory of Green Catalysis of Higher Education Institutes of Sichuan, College of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, Zigong 643000, China. lichenyi1028@163com.
Abstract:
A Lewis-acid-catalyzed redox neutral cascade [1,5]-hydride transfer/cyclization between indolin-2-imines and 2-amino-substituted benzaldehydes has been disclosed. A series of novel, pharmaceutically interesting polycyclic spiroindolenines containing tetrahydroquinolines was obtained in good to excellent yields with excellent diastereoselectivity.
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