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Published on: December 29, 2016
A review on coordination and biological properties of selenosemicarbazone
Vins Daniel1, Vipin Singh1, Prabal Gupta1
1Department of Chemistry, National Institute of Technology-, Tiruchirappalli, Tamil Nadu 620015, India.
Abstract:
The review highlights the synthesis, coordination behavior, and extensive biological activities of selenosemicarbazones and their metal complexes. Over 110 selenosemicarbazone ligands coordinated with metals such as Cu, Ni, Zn, Pt, and Pd are discussed, showcasing significant structural diversity. These compounds uniquely combine the pharmacophoric semicarbazone moiety with selenium, a redox-active trace element, resulting in enhanced stability, reactivity, and biological performance. Coordinated metal complexes demonstrate potent antibacterial, anticancer, antioxidant, and antiparasitic activities. Mechanistic insights include reactive oxygen species (ROS) generation, metalloenzyme inhibition, and DNA binding. Recent developments in structure-activity relationships and therapeutic targeting are emphasized.
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