Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

870
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
870
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.1K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.1K
Antibiotic Selection00:57

Antibiotic Selection

59.3K
Overview
59.3K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Antimicrobial Proteins01:23

Antimicrobial Proteins

12.9K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
12.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbiology Galaxy Lab: The first community-driven gateway for reproducible and FAIR analysis of microbial data.

bioRxiv : the preprint server for biology·2025
Same author

The role of gaming for information, education and communication of AMR: full review of online education resources.

JAC-antimicrobial resistance·2024
Same author

Prediction of Essential Proteins of <i>Klebsiella pneumoniae</i> using Integrative Bioinformatics and Systems Biology Approach: Unveiling New Avenues for Drug Discovery.

Omics : a journal of integrative biology·2024
Same author

Structural insights into the amino acid usage variations in the profilin gene family.

Amino acids·2022

Related Experiment Video

Updated: Jan 7, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.6K

ARKbase: Antimicrobial Resistance Knowledgebase1.0.

Simran Gambhir1, Shweta Pandey1,2, Harsh Bajetha1

  • 1Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.

Nucleic Acids Research
|December 22, 2025
PubMed
Summary
This summary is machine-generated.

ARKbase is a new knowledgebase for antimicrobial resistance (AMR), focusing on WHO priority pathogens. It provides curated data and analysis tools to aid in understanding and combating this global health threat.

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.5K
Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

1.7K

Related Experiment Videos

Last Updated: Jan 7, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.6K
Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.5K
Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

1.7K

Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, often termed a 'silent pandemic.'
  • Effective strategies against AMR require comprehensive, integrated data resources.
  • WHO Bacterial Priority Pathogens are critical targets for AMR research and intervention.

Purpose of the Study:

  • To develop ARKbase, an integrated, curated knowledgebase for antimicrobial resistance (AMR).
  • To focus on WHO Bacterial Priority Pathogens, providing value-added data and analytical tools.
  • To facilitate a holistic understanding of AMR through a combined evidence approach.

Main Methods:

  • Development of ARKbase with three core modules: Database, Insight, and Comparative Analysis.
  • Curated reference and pan-genomes, antimicrobial susceptibility testing (AST) profiles.
  • Deep annotations including AMR genes, virulence factors, drug targets, and transcriptomic data.
  • Quality-checked data adhering to CLSI, EUCAST, and FAIR data principles.

Main Results:

  • ARKbase offers curated genomes, AST profiles, and extensive annotations for priority pathogens.
  • The Insight Module provides 14 sub-modules for detailed data exploration.
  • Comparative Analysis Module enables pathogen comparisons for AMR genes, virulence factors, and drug targets.

Conclusions:

  • ARKbase is the first comprehensive knowledgebase specifically for WHO priority pathogens and AWaRe classification.
  • It enables an integrated, evidence-based approach to understanding and combating AMR.
  • The resource supports research and development of new strategies against antimicrobial resistance.