Personalizing transcranial electrical stimulation

Area of Science:

• Neuroscience
• Neuromodulation
• Brain Stimulation

Background:

• Transcranial electrical stimulation (tES) includes non-invasive techniques like transcranial direct and alternating current stimulation.
• tES modulates the central nervous system for research and therapeutic applications.
• Current fixed tES protocols show variable outcomes due to individual differences.

Purpose of the Study:

• To review emerging strategies for personalizing tES parameters.
• To examine the rationale behind personalized neuromodulation approaches.
• To highlight future directions in optimizing tES efficacy.

Main Methods:

• Review of existing literature on personalized transcranial electrical stimulation.
• Analysis of strategies for tailoring tES parameters.
• Discussion of potential biomarkers for tES response.

Main Results:

• Personalized approaches are increasingly adopted to address tES variability.
• Multiparameter personalization offers a promising avenue for optimization.
• Identifying markers of tES efficacy is crucial for future development.

Conclusions:

• Personalization is essential for reducing variability in tES outcomes.
• Tailored stimulation strategies represent a significant advancement in human brain stimulation.
• While not a complete solution, personalization is a vital step toward reliable neuromodulation.