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Updated: Sep 12, 2025
08:32
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
Published on: May 23, 2025
459
Computational genome engineering through AI-CRISPR-precision medicine integration in modern therapeutics
Oluwaseun E Agboola1, Samuel S Agboola2, Othuke B Odeghe3
1Institute for Drug Research and Development, Bogoro Research Centre, Afe Babalola University, Ado-Ekiti 360001, Nigeria; Damsem Scientific Laboratory and Research, Ado-Ekiti 360102, Nigeria.
Annales Pharmaceutiques Francaises
|August 9, 2025
Summary
Precision medicine, CRISPR gene editing, and artificial intelligence are revolutionizing drug discovery. These technologies show high success rates in clinical trials, addressing unmet medical needs.
Area of Science:
- Pharmaceutical Science
- Molecular Biology
- Biotechnology
Background:
- Precision medicine, CRISPR gene editing, and artificial intelligence (AI) are converging.
- These technologies are driving significant advancements in the pharmaceutical industry.
Purpose of the Study:
- To review the latest trends and future directions of integrated precision medicine, CRISPR, and AI in pharmaceutical science and molecular biology.
- To explore the revolutionary potential of these converging approaches in addressing unmet medical needs and optimizing therapeutic benefits.
Main Methods:
- Synthesis of existing evidence from clinical trials.
- Analysis of regulatory matters.
- Review of technological innovations in gene editing and AI-driven drug discovery.
Main Results:
- Over 250 gene-editing clinical trials are underway globally.
- CRISPR-based therapeutics demonstrate significant clinical success.
- AI drug discovery platforms show 80-90% Phase I trial success rates, surpassing conventional benchmarks.
- Machine learning, multi-omics, and precision medicine are transforming therapeutic development.
Conclusions:
- The integration of precision medicine, CRISPR, and AI is revolutionizing pharmaceutical development.
- These converging technologies offer immense potential for addressing unmet medical needs and enhancing therapeutic outcomes.
- Future directions point towards optimized therapeutic benefits through continued innovation and evidence synthesis.
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