[Proteomics of Oligoasthenoteratozoospermia: Progress in research]

Oligoasthenoteratozoospermia (OAT) is a common male infertility condition characterized by a decreased sperm count and poor sperm motility. The pathogenesis of OAT is rather complicated, involving such factors as lifestyle, genetic abnormalities, environmental pollutants, and others. In recent years, significant progress has been made in the study of sperm proteomics, particularly in its application to the diagnosis and treatment of OAT. This review summarizes the advances in the proteomic studies of sperm and seminal plasma in OAT patients, provides an overview of the potential differentially expressed proteins associated with sperm count and motility, aiming for a deeper insight into the pathogenesis of OAT and improvement of its diagnosis and identification of its related new biomarkers.