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The role of pattern electroretinogram and pattern visual-evoked potentials in ocular hypertension
Di Zhang1,2, Xin Xie1,2, Tian Cheng1,2
1Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Documenta Ophthalmologica. Advances in Ophthalmology
|August 10, 2025
Summary
Pattern electroretinogram (PERG) and patterned visual evoked potential (PVEP) show significant differences in ocular hypertension (OHT) patients. These tests can help differentiate OHT from normal subjects.
Area of Science:
- Ophthalmology
- Neuroscience
- Visual Electrophysiology
Background:
- Ocular hypertension (OHT) is characterized by elevated intraocular pressure.
- Early detection of OHT is crucial to prevent optic nerve damage and vision loss.
- Electrophysiological tests can assess retinal and visual pathway function.
Purpose of the Study:
- To compare pattern electroretinogram (PERG) and patterned visual evoked potential (PVEP) in OHT and normal subjects.
- To evaluate the diagnostic performance of PERG and PVEP parameters in identifying OHT.
Main Methods:
- Cross-sectional observational study comparing 17 OHT patients (34 eyes) with 23 healthy subjects (46 eyes).
- PERG recorded using counter-phasing 48' checkerboard patterns, analyzing P50 and N95 amplitudes and latencies.
- PVEP recorded using 60' and 15' checkerboard pattern reversal stimuli, analyzing P100 amplitudes and latencies.
Main Results:
- OHT group showed significantly prolonged P50 and N95 latencies and reduced amplitudes in PERG (p < 0.05).
- PVEP revealed significantly longer P100 latencies and lower amplitudes for both check sizes in OHT patients (p < 0.001).
- PERG amplitudes (P50, N95) and PVEP P100 latency demonstrated high diagnostic ability (AUC > 0.8).
Conclusions:
- OHT patients exhibit significant abnormalities in PERG and PVEP amplitudes and timing.
- PERG P50/N95 amplitudes and PVEP P100 latency are effective biomarkers for distinguishing OHT from normal individuals.
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