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Related Experiment Video

Updated: Sep 12, 2025

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth
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HVT-delivered chicken IGF-1 improves growth performance in broilers.

Panpan Yang1, Mengjia Xiang1, Minghe Xu1

  • 1College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046 China.

Poultry Science
|August 10, 2025
PubMed
Summary

A novel herpesvirus of turkey vaccine effectively delivers insulin-like growth factor-1 (IGF-1) to broilers, significantly boosting growth and muscle development with a single dose.

Keywords:
BroilersChicken insulin-like growth factor-1Growth performanceHerpesvirus of turkey

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Area of Science:

  • Animal Science
  • Biotechnology
  • Veterinary Medicine

Background:

  • Domesticated poultry are a vital global protein source, with broiler growth efficiency critical for production.
  • Insulin-like growth factor-1 (IGF-1) promotes growth but faces delivery challenges like cost and degradation.
  • Traditional IGF-1 delivery methods are impractical for large-scale poultry farming.

Purpose of the Study:

  • To develop and evaluate an efficient in vivo delivery system for chicken IGF-1.
  • To assess the impact of a recombinant herpesvirus of turkey expressing chicken IGF-1 (rHVT-chIGF-1) on broiler growth performance.

Main Methods:

  • Generated a recombinant herpesvirus of turkey (rHVT) vector expressing chicken IGF-1 (rHVT-chIGF-1).
  • Administered a single intramuscular dose of rHVT-chIGF-1 to broilers at one day of age.
  • Monitored body weight (BW), average daily weight gain (ADG), muscle fiber cross-sectional area (CSA), and gene expression over 42 days.

Main Results:

  • rHVT-chIGF-1 significantly increased broiler BW and ADG at 35 and 42 days compared to control groups.
  • Muscle fiber CSA in pectoral and leg muscles was significantly larger in the rHVT-chIGF-1 group.
  • mRNA expression of muscle development-related genes was upregulated in broilers treated with rHVT-chIGF-1.

Conclusions:

  • rHVT-chIGF-1 serves as a novel and effective in vivo delivery system for promoting chicken growth.
  • This approach offers a promising alternative to traditional, less practical IGF-1 delivery methods in poultry production.