Related Experiment Video
Updated: Sep 12, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Expensive famine: Early hunger experience and diabetes treatment burden
Ge Zhu1, Li Wang2, Wang Xuejun1
1School of Health Management, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
Abstract:
The negative effects of experiencing famine in childhood are not limited to increased morbidity. This study collected hospitalization data for diabetic patients in all hospitals in Gansu Province over a three-year period (2018-2020) and exploited the exogenous shock of the Great Famine event in China (1959-1961). We used a birth cohort DID method to assess the causal relationship between famine survivors and diabetes treatment costs. In a sample of patients with type 2 diabetes, treatment costs were higher for famine survivors than for other patients, especially those born between 1952 and 1957. However, there was no significant difference between patients born between 1959 and 1961, which may challenge the "fetal origin" hypothesis. The costs of hunger are all-encompassing, including worse health before hospitalization, a greater likelihood of surgery, and higher recovery costs after discharge. Findings also hint at differences in the burden of diabetes between insulin-insufficient and sugar-excessive. There are significant differences within survivors of different social statuses, and the low bargaining power of rural and female groups was amplified during the famine. Ethnic differences reflect more complex mechanisms of food acquisition. Even though 63-67 years old is the window period when the burden of diabetic patients who experienced famine in their early life increases significantly, these high medical burdens are effectively compensated under the medical insurance system.
Related Concept Videos
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Symptoms, Diagnosis, and Complications
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Hypoglycemia and Glucagon

