Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Presenting features and outcomes to standard systemic therapies in patients with MTAP-deleted advanced non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Exploring Racial Disparities in Uterine Cancer Survival: A 20-Year, Single-Site Analysis.

Oncology nursing forum·2026
Same author

Demoralization and Associated Factors in Palliative Oncology Outpatients: A Cross-Sectional Study.

Psycho-oncology·2026
Same author

Evaluating the Performance of Large Language Models on Palliative Care Test Questions: A Mixed Methods Study.

Journal of palliative medicine·2026
Same author

Fibroblast growth factor receptor inhibition for succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 2 trial.

Nature medicine·2026
Same author

Geospatial analysis as a tool for identification of potential targetable regions for lung cancer screening interventions in Massachusetts.

Journal of thoracic disease·2026

Related Experiment Video

Updated: Sep 12, 2025

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery
07:30

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery

Published on: May 4, 2022

3.5K

Segmentectomy vs Lobectomy for Occult N1 in Non-Small Cell Lung Cancer: Is Less More?

Mohammad Abdallat1, Rachel T Leo1, Evert A Sugarbaker1

  • 1Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

The Annals of Thoracic Surgery
|August 10, 2025
PubMed
Summary
This summary is machine-generated.

For early-stage non-small cell lung cancer (NSCLC) with occult N1 disease, segmentectomy offers similar overall survival and recurrence-free survival compared to lobectomy. This suggests segmentectomy may be a viable option, sparing patients unnecessary extensive surgery.

More Related Videos

Subcostal Specimen Removal in Completely Portal Robotic Lobectomy
04:38

Subcostal Specimen Removal in Completely Portal Robotic Lobectomy

Published on: April 19, 2024

370
Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection
07:22

Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection

Published on: April 11, 2025

340

Related Experiment Videos

Last Updated: Sep 12, 2025

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery
07:30

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery

Published on: May 4, 2022

3.5K
Subcostal Specimen Removal in Completely Portal Robotic Lobectomy
04:38

Subcostal Specimen Removal in Completely Portal Robotic Lobectomy

Published on: April 19, 2024

370
Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection
07:22

Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection

Published on: April 11, 2025

340

Area of Science:

  • Thoracic Surgery
  • Surgical Oncology
  • Pulmonary Medicine

Background:

  • Segmentectomy is increasingly adopted for early-stage non-small cell lung cancer (NSCLC).
  • The necessity of converting segmentectomy to lobectomy for occult N1 nodal disease remains unclear.
  • This study addresses the impact of resection extent on survival outcomes in patients with occult N1 NSCLC.

Purpose of the Study:

  • To compare overall survival (OS) and locoregional recurrence-free survival (LRFS) between segmentectomy and lobectomy.
  • To evaluate the impact of resection extent in patients with non-small cell lung cancer (NSCLC) and occult N1 disease.
  • To determine if lobectomy offers superior outcomes over segmentectomy in this specific patient group.

Main Methods:

  • Retrospective analysis of patients with NSCLC upstaged to pN1 from cN0 (01/2006-01/2023).
  • Exclusion of patients receiving neoadjuvant treatment or beyond-lobe resection.
  • Propensity-score weighting applied to control for confounders; survival analyzed using Kaplan-Meier and Cox regression.

Main Results:

  • 185 patients with occult N1 disease: 30 segmentectomy, 155 lobectomy.
  • Lobectomy patients had larger tumors (3.4cm vs. 1.95cm, p<0.005).
  • No significant difference in 5-year OS or LRFS between segmentectomy and lobectomy after propensity weighting (weighted OS: 79.69% vs. 66.22%, p=0.401). Procedure type was not a predictor of outcome.

Conclusions:

  • Segmentectomy demonstrates comparable overall survival and locoregional recurrence-free survival to lobectomy for patients with occult N1 NSCLC.
  • Resection extent (segmentectomy vs. lobectomy) does not appear to be a significant predictor of survival in this cohort.
  • Segmentectomy may be a suitable alternative to lobectomy for select patients with occult N1 NSCLC, potentially reducing surgical morbidity.