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Related Concept Videos

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Related Experiment Video

Updated: Sep 11, 2025

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Myocardial Arterial Spin Labeling with Double Inversion Recovery for reduced physiological noise.

Maša Božić-Iven1,2,3, Stanislas Rapacchi4, Yi Zhang1

  • 1Department of Imaging Physics, Delft University of Technology, Delft, The Netherlands.

Magnetic Resonance in Medicine
|August 11, 2025
PubMed
Summary
This summary is machine-generated.

New Double Inversion Recovery (DIR) preparations for myocardial Arterial Spin Labeling (myoASL) significantly reduce physiological noise caused by heart rate variability. This advancement enhances the precision of myoASL-based myocardial blood flow quantification.

Keywords:
cardiac magnetic resonance imagingdouble inversion recoveryflow‐sensitive alternating inversion recoverymyocardial arterial spin labelingmyocardial blood flow

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Area of Science:

  • Cardiovascular MRI
  • Physiological Noise Mitigation
  • Quantitative Perfusion Imaging

Background:

  • Heart rate (HR) variability is a major source of physiological noise (PN) in myocardial Arterial Spin Labeling (myoASL).
  • This noise can compromise the accuracy of myocardial blood flow (MBF) quantification.
  • Conventional myoASL techniques, such as Flow-sensitive Alternating Inversion Recovery (FAIR), are sensitive to HR variations.

Purpose of the Study:

  • To introduce and evaluate Double Inversion Recovery (DIR) preparations for myoASL.
  • To assess the effectiveness of DIR in mitigating heart rate variability-induced physiological noise.
  • To improve the precision of myoASL-based perfusion quantification.

Main Methods:

  • DIR-labeling sequences with double ECG-gating were developed and compared to conventional single-inversion FAIR sequences.
  • DIR preparations involved an immediate reinversion pulse following the FAIR inversion pulse, applied slice-selectively or nonselectively.
  • Simulations, phantom experiments, and in vivo imaging in healthy subjects were used to evaluate PN, SNR, and MBF.

Main Results:

  • DIR-labeling significantly reduced physiological noise in the presence of HR variability.
  • Simulations showed substantial PN reduction and an SNR gain of up to 1.79 for selective DIR.
  • In vivo studies demonstrated a 53% reduction in PN with selective DIR and an average SNR gain of 1.47.

Conclusions:

  • The proposed DIR preparations effectively reduce sensitivity to HR variations in double ECG-gated myoASL.
  • DIR alleviates physiological noise, leading to improved precision in myoASL-based perfusion quantification.
  • This technique offers a more robust approach for assessing myocardial blood flow.