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Updated: Sep 11, 2025
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Published on: August 1, 2019
Assessment of Patient-Reported Outcome Measures in Patients Undergoing Bowel Preparation With Mannitol for
Gian Eugenio Tontini1,2, Cristiano Spada3,4, Peter Uebel5
1Department of Pathophysiology and Organ Transplantation University of Milan Milan Italy.
Background:
Bowel preparation for colonoscopy causes significant discomfort to patients. Large volumes, unpleasant taste, and split-dosing are the main disadvantages of most laxatives. Oral mannitol could be an attractive option because it acts quickly, requires low volumes, and has a pleasant taste.
Aims:
A Phase III study (SATISFACTION) compared oral mannitol with polyethylene glycol-ascorbate (PEG-ADC). This post hoc analysis investigated the effects on patient-reported outcomes (PROMs), mainly concerning the perception of using the preparations.
Methods:
The SATISFACTION Phase III study was an international, multicenter, randomized (1:1), parallel-group, endoscopist-blinded, non-inferiority trial. Taste of preparations, ease of use, and willingness to repeat the preparation with the same product were scored and assessed by the patients.
Results:
Bowel preparation with oral mannitol resulted in a better patient satisfaction profile for all PROMs evaluated.
Conclusion:
Oral mannitol for bowel preparation achieved high patient satisfaction and might be a valuable option for colonoscopy.
Trial Registration:
ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04759885).
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