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Related Experiment Video

Updated: Sep 11, 2025

Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Neonatal Anemia in Preterm Infants: Are We Overtransfusing?

Pravati Jena1, Rojalin Rout1, Rama K Gudu1

  • 1Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

Cureus
|August 11, 2025
PubMed
Summary
This summary is machine-generated.

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This study found that packed red blood cell transfusions for preterm infants often align with international guidelines, though some liberal practices for late anemia suggest room for improvement in transfusion policies.

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Pediatric Transfusion Practices

Background:

  • Preterm infants often require packed red blood cell transfusions (PRBCTs).
  • Adherence to international transfusion guidelines is crucial for optimizing care.
  • Variations in PRBCT practices may exist, particularly in resource-limited settings.

Purpose of the Study:

  • To evaluate the appropriateness of PRBCT practices in preterm infants.
  • To assess adherence to international transfusion guidelines (BCSH, CBS, ANBA).
  • To identify areas for quality improvement in neonatal transfusion protocols.

Main Methods:

  • Retrospective analysis of PRBCTs in preterm neonates (<32 weeks gestation) at a tertiary care center in India.
  • Evaluation of hemoglobin levels against BCSH, CBS, and ANBA transfusion thresholds.
Keywords:
anemiablood transfusionhemoglobinneonateneonatologypacked red blood cell transfusionpretermred blood cell

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  • Consideration of postnatal age and respiratory support status.

    • Main Results:

    • 78 PRBCTs were administered to 43 preterm neonates.
    • Most transfusions (70.5%) occurred at three or more weeks of age.
    • Adherence to guidelines varied: ANBA (100%), BCSH (80.7%), CBS (74.3%).
    • Liberal PRBCT use for late anemia in stable infants was observed, exceeding BCSH and CBS thresholds but aligning with ANBA.

    Conclusions:

    • A liberal approach to PRBCT for late anemia in stable preterm infants was noted.
    • Practices were generally consistent with ANBA guidelines, but showed variation with BCSH and CBS.
    • Quality improvement interventions are recommended to refine PRBCT policies and prevent potential over-transfusion.