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Updated: Sep 11, 2025
A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
Relationship between eosinopenia and neutrophil-lymphocyte ratio with sepsis-related mortality in the intensive care
Parviz Amri1, Armin Nejadnaderi2, Hemmat Gholinia1
1Clinical Research Development Unit of Ayatollah Rouhani Hospital, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Background:
Early diagnosis of sepsis can lead to rapid initiation of treatment and reduced mortality. The aim of this study was to investigate the relationship between eosinopenia and neutrophil-lymphocyte ratio (NLR) with sepsis-related mortality in the intensive care unit.
Results:
Out of 100 patients studied, 59 patients survived and 41 patients died and the mean age of the patients was 63.27±16.13 years. Out of 40 patients with eosinopenia, 19(46.3%) died and out of 60 patients with normal eosinophil, 22(53.7%) died (P=0.28). The NLR on the first day in died patients was significantly higher than in the surviving patients (P=0.009). The increase in SOFA Score (p<0.001 and OR=1.49) and the increase in NLR (P=0.02 and OR=3.38) has a direct relationship with the mortality rate.
Conclusion:
The results of the present study in sepsis patients showed that patients who had a higher neutrophil-to-lymphocyte ratio had higher mortality and there was no relationship between eosinopenia and mortality rate.
