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Serum fibrinogen & total cholesterol: A significant primary biomarker and its interrelationship in stroke
Komal Rana1, Tarunkumar Chavda2, Sonal Chavda2
1Department of Medicine, Parul Sevashram Hospital (PSH), Parul Institute of Medical Sciences and Research (PIMSR), Parul University, Vadodara, Gujarat, India.
Insights
Elevated plasma fibrinogen and total cholesterol are key indicators for cardiovascular stroke. This study found higher incidences in the ischemic stroke group, highlighting these biomarkers
Area of Science:
- Neurology
- Cardiovascular Medicine
- Biochemistry
Background:
- Stroke is a leading cause of disability and mortality worldwide.
- Plasma fibrinogen and total cholesterol are implicated in cardiovascular disease.
- Understanding their role in stroke etiology is crucial for prevention and treatment.
Purpose of the Study:
- To investigate the association between plasma fibrinogen and total cholesterol levels and stroke.
- To analyze the incidence, prevalence, and gender distribution across different stroke etiologies.
Main Methods:
- Retrospective analysis of patient data including routine investigations and radiological findings.
- Assessment of plasma fibrinogen and total cholesterol levels.
- Categorization of stroke into ischemic (IS) and hemorrhagic (HS) types.
Main Results:
- The study included 510 patients (292 males, 218 females) aged 30-80.
- Elevated plasma fibrinogen (81%) and total cholesterol (73.2%) were observed in a significant proportion of patients.
- Ischemic stroke (73%) was more prevalent than hemorrhagic stroke (27%).
- Middle Cerebral Artery territory infarctions were common in IS.
- Comorbidities like diabetes and hypertension were prevalent.
Conclusions:
- Elevated plasma fibrinogen and total cholesterol are significant independent biomarkers for ischemic stroke.
- Stroke incidence is higher in the ischemic stroke subgroup.
- These findings underscore the importance of managing lipid and fibrinogen levels for stroke prevention.
Background:
To study the association of plasma fibrinogen & total cholesterol levels, incidences, prevalence, and gender wise distribution in different etiologies of stroke.
Methods:
Fibrinogen & total cholesterol levels, prevalence, incidences, comorbidities, and different etiologies were assessed along with routine investigations and radiology inputs as per investigator's discretion. The overall median values were represented in graphically format in MS-Excel.
Results:
292 Males: 218 females. Age 30 to 80 years. Among, 25.1% diabetic, 38.9 % hypertension (HTN) and 31% diabetes + HTN. 5 % diabetes + HTN + dyslipidemia and other comorbidities. Overall, 73% had ischemic stroke (IS) & 27 % have hemorrhagic stroke (HS). Hemiparesis in 76.5 %. Mean Fibrinogen elevated in 81% and range was 934±20 mg/dL. Total cholesterol level increased in 73.2% & range was 365±10 mg/dL. The HS patients were experienced headache 77 (19.60%) and vomiting 34 (24.6%) than IS patients. As per radiological finding, the territory of Middle Cerebral Artery was the ordinary location of arterial territory infarctions in the IS form that was present in 213 (57.2%) subjects following that in the anterior side of cerebral artery in 89 (23.92%) and posterior cerebral artery was 44 (11.82%). Arterial flutter found in 56 (10.9%), Structural heart disease present in 30 (5.88%), family history of stroke in 28 (5.49%).
Conclusion:
Elevated fibrinogen & total cholesterol levels are independent significant primary biomarkers elevated with incidences of CV stroke. Stroke was higher in ischemic stroke group.
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