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Updated: Sep 11, 2025

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Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
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Adapting Cognitive Behavioral Therapy for Depression After Traumatic Brain Injury: A Case Study
Lauren B Fisher1, Andrew J Curreri2, Sunday Hull3
1Massachusetts General Hospital and Harvard Medical School.
Cognitive and Behavioral Practice
|August 11, 2025
Summary
This case study shows that cognitive-behavioral treatment for depression adapted for traumatic brain injury (CBT-TBI) significantly reduced depression and anxiety symptoms in a patient. The adapted therapy addresses the unique needs of individuals with TBI sequelae.
Area of Science:
- Neuroscience
- Psychiatry
- Rehabilitation Medicine
Background:
- Traumatic brain injury (TBI) often leads to depression and anxiety.
- Traditional cognitive-behavioral therapy (CBT) may require adaptation for individuals with TBI sequelae.
- There is a need for effective mental health interventions for TBI survivors.
Purpose of the Study:
- To describe a cognitive-behavioral treatment for depression adapted for individuals with TBI (CBT-TBI).
- To present a case study of a patient with TBI who received CBT-TBI and experienced symptom reduction.
- To highlight the adaptations made to traditional CBT for depression.
Main Methods:
- A case study design within a randomized, waitlist-controlled trial.
- A patient with complicated mild TBI, depression, anxiety, and post-concussive symptoms received 12 in-person CBT-TBI sessions.
- Clinician-rated, self-rated, and neuropsychological measures were used for assessment at baseline and posttreatment.
Main Results:
- The patient demonstrated a clinically significant reduction in depression and anxiety symptoms.
- Improvements were observed in coping abilities and adaptive thinking.
- The Reliable Change Index (RCI) indicated meaningful symptom improvement.
Conclusions:
- CBT-TBI is a viable treatment for reducing depression and anxiety in individuals with TBI.
- Adaptations in structure, content, and process are crucial for effective CBT in TBI populations.
- Therapist flexibility, ongoing assessment, collaboration, and feedback are vital for successful treatment delivery.
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