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Deprescribing in Patients with Intellectual Disability.

Larrilyn Grant1, Kari Harper1, Julie P Gentile1

  • 1All authors are with the Department of Psychiatry at Wright State University in Dayton, Ohio.

Innovations in Clinical Neuroscience
|August 11, 2025
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Summary
This summary is machine-generated.

Individuals with intellectual disability (ID) experience higher rates of mental illness and polypharmacy. Adapted psychotherapy and deprescribing protocols can improve quality of life for these patients.

Keywords:
Intellectual disabilitycardiometabolic side effectsdeprescribingextrapyramidal side effectsoff-label prescribingpharmacologic treatmentpolypharmacypsychotherapy

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Area of Science:

  • Psychiatry
  • Intellectual Disability Research
  • Pharmacology

Background:

  • Mental illness is more prevalent in individuals with intellectual disability (ID) compared to the general population.
  • Individuals with ID often have limited coping mechanisms and support systems, increasing vulnerability to stress.
  • Polypharmacy is common in patients with co-occurring ID and mental illness, often continuing after institutional discharge.

Purpose of the Study:

  • To review the application of adapted psychotherapy for patients with intellectual disability.
  • To discuss deprescribing protocols for managing polypharmacy in this population.
  • To highlight strategies for improving the quality of life for individuals with ID and mental illness.

Main Methods:

  • Review of adapted psychotherapy techniques suitable for individuals with ID.
  • Examination of deprescribing protocols and their effectiveness in reducing polypharmacy.
  • Analysis of case studies illustrating diagnostic and treatment approaches.

Main Results:

  • Adapted psychotherapy can be effective for individuals with ID.
  • Deprescribing protocols offer a structured approach to reducing unnecessary medications.
  • Integrated mental and physical health management is crucial for this population.

Conclusions:

  • Psychotherapy, adapted for intellectual disability, can enhance mental health outcomes.
  • Systematic deprescribing is essential for managing polypharmacy and improving patient safety.
  • Comprehensive care strategies are needed to improve the quality of life for individuals with ID and co-occurring mental illness.