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Updated: Sep 11, 2025

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

926

Periprosthetic Joint Infection (PJI)

Naeemeh Kalali, Mohammad H Ebrahimzadeh, Ali Moradi

    The Archives of Bone and Joint Surgery
    |August 11, 2025
    PubMed

    Insights

    Periprosthetic joint infection (PJI) is a complex orthopedic complication. This review explores PJI concepts, current treatments, and novel prevention strategies, focusing on proactive methods to combat these infections.

    Area of Science:

    • Orthopedic Surgery
    • Infectious Diseases
    • Biomaterials Science

    Background:

    • Periprosthetic joint infection (PJI) is a severe complication following joint arthroplasty.
    • PJIs lead to high healthcare costs, increased mortality, and significant patient morbidity.
    • Current diagnostic criteria and treatment protocols for PJI lack universal standardization.

    Purpose of the Study:

    • To provide a comprehensive overview of the concept of periprosthetic joint infection (PJI).
    • To review existing treatment options for managing PJIs.
    • To highlight novel strategies and preventive measures for controlling and preventing PJIs.

    Main Methods:

    • Literature review of existing studies on PJI.
    • Analysis of current diagnostic and treatment modalities.
    • Exploration of emerging preventive techniques, including material coatings.

    Main Results:

    • PJI management is challenging due to undefined diagnostic standards and debated treatment efficacy.
    • Existing treatments are reactive, addressing PJI after occurrence.
    • Innovative strategies, particularly material coatings, show promise for PJI prevention.

    Conclusions:

    • Standardization of PJI definition and diagnosis is crucial.
    • Proactive and preventive strategies are essential for combating PJIs.
    • Further research into novel preventive methods, such as advanced material coatings, is warranted.

    Keywords:
    Joint arthroplastyOrthopedicPeriprosthetic joint infection

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