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The Extracellular Matrix01:42

The Extracellular Matrix

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Updated: Sep 11, 2025

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Translational Extracellular Matrix Spray-Coating Approach for Large-Scale Bioactive Surface Functionalization and

Albertus Ivan Brilian1, Chaeeon Lim1, Grant Lee2

  • 1Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 04107, Republic of Korea.

Advanced Healthcare Materials
|August 11, 2025
PubMed
Summary

Spray-coating extracellular matrix (ECM) proteins like fibronectin and collagen enhances tissue repair. This scalable method improves wound closure and matrix organization for regenerative medicine applications.

Keywords:
extracellular matrixspray coatingwound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Extracellular matrix (ECM) delivery platforms show promise for tissue repair.
  • Clinical translation is hindered by scalability, fragility, and substrate limitations.

Purpose of the Study:

  • To develop a scalable spray-coating technique for activating ECM proteins.
  • To functionalize diverse biomedical substrates with fibronectin (FN) and collagen (COL).

Main Methods:

  • Utilized a spray-coating strategy with a commercial airbrush for uniform droplet deposition.
  • Conformationally activated FN and COL via mechanical unfolding during spray deposition.
  • Applied sprays to various substrates including sutures and dressings.

Main Results:

  • Spray-coating achieved uniform ECM deposition without damaging substrates.
  • Conformationally activated FN enhanced cell adhesion.
  • Multi-ECM sprays promoted fibrillogenesis, matrix organization, and fibroblast activity.
  • Achieved 88.2% wound closure and 66.6% COL density in a murine wound model.

Conclusions:

  • ECM spray-coating is a scalable and bioactive platform for wound therapy.
  • This method offers advanced surface functionalization for regenerative medicine.
  • The technique overcomes limitations of traditional ECM delivery systems.