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Updated: Sep 11, 2025
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
A Pd nanoparticle-loaded nanoscale covalent organic framework to enhance tumor therapy by synergistic
Kai-Xuan Zhang1, Meng-Yan Gao1, Yan-Zheng Lu1
1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China. yananli@sdnu.edu.cn.
Abstract:
Herein, we report a nanoscale composite COF material loaded with Pd nanoparticles and H2via a stepwise post-synthetic modification. The obtained PdH0.18@COF was shown to affect mitochondrial function by disrupting the intracellular redox balance and thus down-regulating the expression of heat shock proteins (HSPs), thereby enhancing the photothermal therapy of tumors.
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