Related Experiment Video
Updated: Sep 11, 2025
09:08
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
6.8K
Deciphering NOTCH1 as a Biomarker in Adenoid Cystic Carcinoma: Insights From a Systematic Review With Meta-Analysis
Isabela de Sousa Slivar1, Bruno de Andrade Zanesco1, Manoela Domingues Martins2,3
1Department of Dentistry, School of Dentistry, Universidade de São Paulo (FOUSP), São Paulo, Brazil.
Summary
NOTCH1 alterations are linked to prognosis in adenoid cystic carcinoma (ACC). NOTCH1 mutations, Notch1, and NICD1 expression predict survival outcomes, aiding ACC risk stratification.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- NOTCH1 alterations are frequently implicated in adenoid cystic carcinoma (ACC) prognosis.
- Existing research findings on NOTCH1's prognostic role in ACC are fragmented.
- An integrative analysis is needed to consolidate the evidence on NOTCH1-related biomarkers in ACC.
Purpose of the Study:
- To conduct an integrative analysis of NOTCH1-related biomarkers in adenoid cystic carcinoma (ACC).
- To evaluate the prognostic value of NOTCH1 alterations, including mutations and protein expression, in ACC.
- To determine the association between NOTCH1 biomarkers and survival outcomes in ACC patients.
Main Methods:
- A comprehensive literature search was performed across multiple scientific databases.
- Inclusion criteria focused on studies examining NOTCH1 features at ACC diagnosis and their correlation with survival.
- Meta-analysis was employed for studies with similar methodologies to synthesize results.
Main Results:
- Twelve studies met the inclusion criteria, analyzing NOTCH1 mutational status, Notch1 immunoexpression, and NICD1 immunoexpression.
- NOTCH1 alterations were associated with overall survival, disease-free survival, and progression-free survival.
- Meta-analyses revealed increased risks: 2.31-fold for death with NOTCH1 mutations, 2.6-fold for death with positive NICD1 expression, and 1.91-fold for recurrence with high Notch1 expression.
Conclusions:
- This review highlights the significant prognostic relevance of NOTCH1 in adenoid cystic carcinoma.
- NOTCH1-related biomarkers demonstrate potential as valuable tools for risk stratification in ACC.
- Further research integrating these biomarkers could refine patient management and treatment strategies.
Related Concept Videos
03:14Notch Signaling Pathway
4.4K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.4K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K