Terahertz metasensor with pseudo parity time symmetry for oral cancer diagnostics

This study presents the design and theoretical analysis of a pseudo parity-time symmetric photonic crystal biosensor for early oral cancer detection. Using the transfer matrix method, we numerically investigated the resonant transmission properties of a 1D photonic crystal structure with a central defect layer (D = 50 μm) containing healthy and cancer oral cells. The proposed [Formula: see text] configuration exhibits exceptional sensitivity, quantified by two key metrics: a spectral sensitivity of 118 GHz/RIU and an extraordinary transmittance sensitivity of [Formula: see text] These results demonstrate significant improvements over conventional photonic biosensors, enabled by the PT-symmetric design's ability to operate near an exceptional point. The optimized structure achieves ultra-sharp resonances ([Formula: see text] THz FWHM) with remarkable field enhancement, making it particularly suitable for detecting minute refractive index changes associated with malignant transformations. Our findings establish a foundation for developing high-performance, label-free diagnostic tools for early-stage oral cancer detection.