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Updated: Sep 11, 2025
![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)
Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB
Published on: June 28, 2011
Electrochemical Conversions of Sulfinamidines into Sulfonimidoyl Fluorides
Ding-Bo Zeng1, Bin Zhao1, Chen-Xu Gong1
1Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.
Abstract:
Sulfonimidoyl fluorides, the chiral aza-isosteres of sulfonyl fluorides, have gained increasing attention as a powerful linkage agent in the sulfur(VI)-fluoride exchange reaction (SuFEx). The hexavalent sulfonimidoyl fluorides are typically prepared from organosulfur in high oxidation states. We report herein an electrochemical approach using the readily available, bench-stable, yet underexplored tetravalent sulfinamidines without external chemical oxidants. The usefulness of the obtained sulfonimidoyl fluorides is demonstrated by their versatile SuFEx reactivity.
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