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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Cobalt-Catalyzed Alkene Alkylarylation: Access to Pyrrolidinones
Junda Wang1, Kaixin Chen1, Changrui Nie1
1Key Laboratory of Organic Synthesis of Jiangsu Province, Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Abstract:
Practical cyclization and cross-coupling reactions between alkenyl-substituted alkyl bromides and arylzinc pivalates via cobalt-catalyzed sequential C(sp3)-C(sp3)/C(sp3)-C(sp2) bond formation have been disclosed, thus providing straightforward access to structurally diverse pyrrolidinones. Moreover, this approach could be also effective for the modular preparation of spirocyclic pyrrolidinones through spirocyclized alkene alkylarylation. Beyond that, rather mild conditions, synthetic simplicity, and excellent functional group compatibility show the potential applications of this method in synthetic chemistry.
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