Jove
Visualize
Contact Us

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

6.3K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
6.3K
Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

915
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
915

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Category-selective neural decreases in the human ventral occipito-temporal cortex as defined with intracranial recordings.

NeuroImage·2026
Same author

Effects of transcranial electrical stimulation on face identification and related perceptual processes: a systematic review.

Psychological research·2026
Same author

Cortical and white matter myelination proceed in concert during early infancy.

Nature communications·2026
Same author

Effectiveness of artificial intelligence in nursing simulation education: A systematic review, meta-analysis and bibliometric visualization analysis.

Nurse education today·2026
Same author

Cortical categorization of facial expressions: Threat priority or local configural saliency?

NeuroImage·2026
Same author

The critical role of the right anterior fusiform gyrus in unfamiliar face identity discrimination.

Brain structure & function·2026
Same journal

Restraint of melanoma progression by cells in the local skin environment.

eLife·2026
Same journal

Brawn before bite in endemic Asian eutherian mammals after the end-Cretaceous extinction.

eLife·2026
Same journal

Experimental evolution to thermal stress indicates climate resilience in a cosmopolitan arthropod.

eLife·2026
Same journal

Correlates of protection against African swine fever virus identified by a systems immunology approach.

eLife·2026
Same journal

Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.

eLife·2026
Same journal

Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation.

eLife·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 11, 2025

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
10:33

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

12.9K

A tight relationship between BOLD fMRI activation/deactivation and increase/decrease in single neuron responses in

Marie-Alphée Laurent1, Corentin Jacques1, Xiaoqian Yan2

  • 1Université de Lorraine, CNRS, IMoPA, Nancy, France.

Elife
|August 12, 2025
PubMed
Summary
This summary is machine-generated.

Researchers investigated how neural firing rates relate to brain activity signals measured by functional magnetic resonance imaging (fMRI). They found that face-selective neurons in the human brain can both increase and decrease their firing rates, clarifying the physiological basis of fMRI signals.

Keywords:
BOLD activationBOLD deactivationfMRIface-selectivityhumanintracerebral recordingsneurosciencesingle neurons

More Related Videos

Real-Time fMRI Brain Mapping in Animals
04:05

Real-Time fMRI Brain Mapping in Animals

Published on: September 24, 2020

3.7K
Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.2K

Related Experiment Videos

Last Updated: Sep 11, 2025

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
10:33

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

12.9K
Real-Time fMRI Brain Mapping in Animals
04:05

Real-Time fMRI Brain Mapping in Animals

Published on: September 24, 2020

3.7K
Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.2K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • The relationship between Blood-Oxygen-Level-Dependent (BOLD) signals in functional magnetic resonance imaging (fMRI) and underlying neural firing rates is not fully understood, particularly in human association cortex.
  • Previous studies have primarily focused on increases in BOLD signals correlating with neural activity, leaving the interpretation of BOLD decreases less clear.

Purpose of the Study:

  • To directly contrast neuronal activity with fMRI signals in adjacent brain regions of the human fusiform gyrus (FG).
  • To investigate whether face-selective neural activity is exclusively associated with increased neural firing or if it can also involve decreased firing rates.

Main Methods:

  • Utilized direct electrophysiological recordings of single neurons (single units) in the human fusiform gyrus.
  • Employed frequency-tagging stimulation to objectively identify face-selective neurons.
  • Contrasted neuronal activity in lateral FG (associated with fMRI increases) and medial FG (associated with fMRI decreases) during face perception.

Main Results:

  • Approximately 70% of recorded neurons were identified as face-selective.
  • Neurons in the lateral FG showed a selective increase in firing rate in response to faces.
  • Neurons in the medial FG exhibited a selective decrease in spiking activity to faces, with about a third showing genuine suppression of baseline activity.

Conclusions:

  • Human face-selective neural activity can be expressed as both increases and active suppressions (decreases) in spiking activity.
  • These findings provide crucial insights into the physiological basis of the fMRI signal, explaining both positive and negative BOLD responses.
  • The study clarifies the nature of neural processing in the fusiform gyrus during face perception.