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    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Optical Physics

    Background:

    • Dual-modal imaging systems offer complementary information for enhanced diagnostic capabilities.
    • Integrating Optical Coherence Tomography (OCT) and Photoacoustic Microscopy (PAM) presents a powerful approach for biological tissue analysis.
    • Existing OCT-PAM systems can be complex and bulky, limiting their practical application.

    Purpose of the Study:

    • To propose and validate a novel, non-contact, all-optic dual-modal OCT-PAM system.
    • To simplify the system design by utilizing a single broadband light source for both OCT and PAM.
    • To demonstrate the system's capability for diverse biological imaging applications.

    Main Methods:

    • A homodyne low-coherence interferometer was employed to detect photoacoustic-induced vibrations.
    • The OCT and PAM modalities shared a single broadband light source, enabling a compact and integrated system.
    • The system was tested using absorption-scattering imaging of human hairs and in vivo imaging of mouse vasculature.

    Main Results:

    • Successful demonstration of a compact, non-contact, all-optic OCT-PAM dual-modal system.
    • Acquisition of absorption-scattering images of human hairs.
    • Measurement of mouse femoral artery and vein flow rates and in vivo imaging of mouse auricle blood vessels.

    Conclusions:

    • The proposed single-light-source OCT-PAM system is simplified and compact.
    • This dual-modal approach provides complementary biological tissue information.
    • The system offers a richer reference for disease diagnosis and biomedical research.