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Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

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Fluoropolymers in Medical Applications: Recent Progress and Development.

Chadron M Friesen¹, Jason Pulfer²

¹Neufeld Science Centre, Department of Chemistry, Trinity Western University, 22500 University Drive, Langley, British Columbia V2Y 1Y1, Canada.

Chemical Reviews

|August 12, 2025

Summary

Fluoropolymers are essential medical materials, widely used in drug delivery, implants, and wound care. Research highlights their importance in long-term patient interventions, balancing environmental persistence with medical necessity.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Medical Device Technology

Background:

Fluoropolymers offer unique properties beneficial for medical applications.
Their use spans diverse areas including drug delivery, implants, sensors, and wound care.
A significant body of research exists, with a focus on poly(tetrafluoroethylene) (PTFE) and poly(vinylidene difluoride) (PVDF).

Purpose of the Study:

To conduct a comprehensive review of medical applications of fluoropolymers.
To analyze the scope and trends in fluoropolymer use in medicine from 2019 to October 2024.
To identify key application areas and prevalent polymer types.

Main Methods:

Systematic literature search of scientific articles.
Filtering and selection of relevant studies focusing on medical applications.
Categorization of applications and identified fluoropolymer types.

Main Results:

291 out of 532 reviewed articles were relevant to medical applications.
Identified 16 specific application categories for fluoropolymers in medicine.
Poly(tetrafluoroethylene) (PTFE) and poly(vinylidene difluoride) (PVDF) were the most frequently studied fluoropolymers.
The review period covered 2019 to October 2024.

Conclusions:

Fluoropolymers are critical for effective medical treatments, particularly for long-term interventions.
Balancing environmental persistence with material longevity in medical devices is a key consideration.
Further research is needed to explore a wider range of fluoropolymers beyond PTFE and PVDF.