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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

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Progressive silent cerebral infarction is associated with stroke and persistent cognitive impairment in survivors of

Jia Yu1, Jenna Brown2, Jacob Meade2

  • 1School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.

Blood Advances
|August 12, 2025
PubMed

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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