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Cracking the Code of a Preclinical Rodent Model of HFpEF: The Mitochondrial Link

Chae-Myeong Ha1, Adam R Wende1

  • 1Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

JACC. Basic to Translational Science
|August 12, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
HFpEFcardiac remodelingheart failuremetabolismmitochondria

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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