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Paediatric Nasal Septal Perforations Systematic Review: Etiologies, Symptoms, and Treatment Outcomes

Arjun Sharma1,2, Nihal Punjabi1, Lana Mamoun2,3

  • 1California University of Science and Medicine, School of Medicine, Colton, California, USA.

Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
|August 12, 2025
PubMed

Insights

Pediatric nasal septal perforations are often caused by medical procedures or trauma. Surgical repair shows high success rates, though outcomes vary with specific causes like autoimmune conditions or foreign bodies.

Area of Science:

  • Otolaryngology
  • Pediatric Surgery
  • Medical Research

Background:

  • Nasal septal perforations (NSPs) in children present unique challenges.
  • Understanding the causes and treatment outcomes is crucial for effective management.

Purpose of the Study:

  • To review the causes, symptoms, and surgical outcomes of NSPs in pediatric patients.
  • To synthesize current evidence through a systematic review and meta-analysis.

Main Methods:

  • Systematic review and meta-analysis of studies on pediatric NSPs.
  • Searched PubMed, Embase, and Web of Science databases.
  • Included studies with data on patients aged 0-18 with NSPs and their etiologies.

Main Results:

  • Analyzed 9 retrospective studies involving 219 pediatric patients.
  • Most common causes: iatrogenic (34.25%), traumatic (23.29%), idiopathic (18.26%).
  • High surgical closure rate of 86%; lower success in autoimmune/foreign body cases. No size-perforation correlation.

Conclusions:

  • Iatrogenic and traumatic factors are primary causes of pediatric NSPs.
  • Foreign body-related defects are common in this age group.
  • Surgical repair of pediatric NSPs generally yields high closure rates.
Abstract

Keywords:
etiologiesnasal septal perforationpaediatrics closure rate

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