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Related Concept Videos

Three-Dimensional Microscopy in Microbiology01:28

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Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
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Related Experiment Video

Updated: Sep 11, 2025

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics
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Toward low-noise on-chip plasmonic three-dimensional biological cell imaging.

Maliha Momtaj, Muhammad Anisuzzaman Talukder

    Optics Express
    |August 13, 2025
    PubMed
    Summary

    We developed a portable 3D cell imaging platform using silicon photonics and surface plasmon coupled emission (SPCE). This innovative technology enables accessible disease detection and diagnosis at the point-of-care.

    Area of Science:

    • Photonics
    • Biomedical Imaging
    • Nanotechnology

    Background:

    • Affordable and efficient cell imaging is crucial for disease detection.
    • Existing tools often lack portability and user-friendliness.
    • There is a need for advanced imaging solutions for point-of-care applications.

    Purpose of the Study:

    • To introduce a compact, portable, and user-friendly 3D cell imaging platform.
    • To leverage silicon photonics and surface plasmon coupled emission (SPCE) for enhanced imaging.
    • To develop an imaging algorithm for 3D reconstruction from SPCE signals.

    Main Methods:

    • Designed a specialized slide with an integrated SPCE structure and silicon nitride (SiN) waveguide.
    • Utilized a grooved array for light coupling into the waveguide and edge coupling for excitation.

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  • Developed a novel imaging algorithm based on emitted light patterns for 3D reconstruction.

    • Main Results:

    • Demonstrated a functional 3D cell imaging platform.
    • Achieved precise excitation of fluorescently labeled cells without external filters.
    • The developed algorithm successfully reconstructs 3D cell images from SPCE signals.

    Conclusions:

    • The developed platform offers an innovative approach to accessible and efficient cell imaging.
    • This technology has the potential to significantly impact point-of-care diagnostics.
    • The fusion of silicon photonics, SPCE, and computational imaging enables portable 3D cell analysis.