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Magnetic Resonance Imaging

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Updated: Sep 11, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Dual-encoded magnetization transfer and diffusion imaging and its application to tract-specific microstructure

Ilana R Leppert¹, Pietro Bontempi², Christopher D Rowley^1,3

¹McConnell Brain Imaging Centre, Montreal Neurological institute and Hospital, Montreal, Canada.

Imaging Neuroscience (Cambridge, Mass.)

|August 13, 2025

Summary

A new dual-encoded magnetization transfer (MT) and diffusion MRI sequence can map white matter tracts at the sub-voxel level. This method improves sensitivity to microstructural changes in specific brain pathways.

Keywords:

connectome diffusion dual-encoding magnetization transfer microstructure myelin

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Area of Science:

Neuroimaging
Biophysics
Diffusion MRI

Background:

Magnetization transfer (MT) and diffusion MRI are crucial for characterizing white matter microstructure.
Existing methods often struggle with partial volume effects, limiting tract-specific analysis.
Resolving sub-voxel properties of white matter tracts remains a challenge.

Purpose of the Study:

To introduce and validate a novel dual-encoded MT and diffusion-weighted MRI sequence.
To assess the sequence's ability to measure tract-specific MT ratios (MTR) at the sub-voxel level.
To compare the performance of a novel analysis technique (COMMIT) against conventional MTR tractometry.

Main Methods:

A novel dual-encoded MT and diffusion sequence was designed and optimized for MTR efficiency.
A whole-brain protocol with 2.6 mm isotropic resolution was developed, with a scan time under 7 minutes.
Tract-specific MTR was extracted using Convex Optimization Modeling for Microstructure Informed Tractography (COMMIT) and compared to conventional MTR tractometry in ten healthy subjects.

Main Results:

The dual-encoded sequence achieved maximal MTR efficiency with a rapid whole-brain acquisition.
The COMMIT method reliably resolved MTR for major white matter pathways.
Tract-specific analysis using COMMIT demonstrated reduced susceptibility to partial volume effects compared to conventional tractometry.

Conclusions:

The novel dual-encoded MT and diffusion sequence enables sub-voxel characterization of white matter microstructure.
This technique enhances sensitivity to microstructural alterations in specific tracts, relevant for disease, aging, and learning studies.
The findings pave the way for more anatomically specific weighted structural connectomes.