[Acute renal insufficiency: 1st manifestation of familial sarcoidosis]

We report an unusual case of sarcoidosis remarkable for: 1) The presentation as acute irreversible renal failure with interstitial granulomas and ischemic glomerular lesions. This leads to a discussion of the possibility of perivascular granulomas or the existence of a vasculitis. 2) The unusual localisation of other lesions in the stomach and cutaneous tissues with a necrotising epidermal vasculitis, unusual in sarcoidosis. 3) The existence, in the patient's mother, of nasal mucosal sarcoidosis and also a carrier of the B8 and DR3 antigens.