Jove
Visualize
Contact Us

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

6.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictive acoustical processing in human cortical layers.

Nature communications·2026
Same author

Predictive acoustical processing in human cortical layers.

bioRxiv : the preprint server for biology·2025
Same author

Investigations of hypoxia-induced deoxyhemoglobin as a contrast agent for cerebral perfusion imaging.

Human brain mapping·2022
Same author

Perfusion MRI using endogenous deoxyhemoglobin as a contrast agent: Preliminary data.

Magnetic resonance in medicine·2021
Same author

Quantitative and simultaneous measurement of oxygen consumption rates in rat brain and skeletal muscle using <sup>17</sup> O MRS imaging at 16.4T.

Magnetic resonance in medicine·2020
Same author

Direct visualization and characterization of the human zona incerta and surrounding structures.

Human brain mapping·2020
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 11, 2025

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
09:33

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges

Published on: December 17, 2014

14.1K

Problems and solutions in quantifying cerebrovascular reactivity using BOLD-MRI.

Jacob B Schulman1,2, Kamil Uludağ1,2,3,4,5

  • 1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Imaging Neuroscience (Cambridge, Mass.)
|August 13, 2025
PubMed
Summary
This summary is machine-generated.

Cerebrovascular reactivity (CVR) imaging using BOLD-MRI (CVR_BOLD) is widely used but doesn't always reflect true physiological CVR. This study reveals CVR_BOLD

Keywords:
BOLDCVRMRIdeoxyhemoglobinsimulations

More Related Videos

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
10:33

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

12.9K
Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
05:23

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

645

Related Experiment Videos

Last Updated: Sep 11, 2025

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
09:33

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges

Published on: December 17, 2014

14.1K
Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
10:33

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

12.9K
Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
05:23

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

645

Area of Science:

  • Neuroimaging
  • Vascular Physiology
  • Biomedical Engineering

Background:

  • Cerebrovascular reactivity (CVR) assesses cerebral blood vessel function.
  • Physiological CVR measures (blood flow, velocity, volume) face acquisition challenges.
  • Blood oxygenation level-dependent (BOLD)-MRI CVR (CVR_BOLD) is common but indirect.

Purpose of the Study:

  • To comprehensively evaluate the quantitative accuracy and limitations of CVR_BOLD.
  • To determine how CVR_BOLD relates to physiological CVR measures.
  • To identify key parameters influencing CVR_BOLD variations.

Main Methods:

  • Developed a CVR_BOLD simulation framework.
  • Analyzed existing CVR_BOLD literature data.
  • Compared CVR_BOLD with physiological CVR and various influencing factors.

Main Results:

  • CVR_BOLD does not consistently mirror physiological CVR.
  • CVR_BOLD is sensitive to physiological factors (hematocrit) and acquisition parameters (field strength).
  • Stimulus protocols, resting-state vs. breath-hold, and disease states (stenosis, steal) impact CVR_BOLD interpretation.

Conclusions:

  • CVR_BOLD requires careful interpretation due to its indirect nature and variability.
  • Understanding CVR_BOLD's dependencies is crucial for accurate cerebrovascular assessment.
  • This work enhances quantitative CVR imaging in clinical and research settings.